Closed

Accelerating Product Excellence in Innovation and for Clinical Adoption (APEx) (U24 Clinical Trial Not Allowed)

Federal funding opportunity RFA-DE-27-002 from National Institutes of Health (Department of Health and Human Services).

Posted: May 4, 2026
Closed: July 10, 2026
Award ceiling: $4,000,000
Program funding: $6,000,000
Cost sharing: No
Instrument: Cooperative Agreement
Assistance listing: 93.867, 93.121, 93.846
Category: Health
Archives: September 8, 2026

Program funding history

Awards made under Assistance Listing 93.867 (one of 3 on this opportunity) across FY2025–FY2027, from public federal spending records.

FY2025 obligated: $696.7M
FY2026 obligated: $693.8M
FY2027 (to date) obligated: $0
Awards in window: 3,058

Top recipients: The Johns Hopkins University, The Leland Stanford Junior University, Jaeb Center for Health Research Foundation, Inc., Regents of the University of California, San Francisco, the, University of California, Los Angeles

Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →

This opportunity is closed. Applications are no longer accepted. Similar grants are listed below, and the free Tuesday digest carries the next ones like it.

Synopsis

This Notice of Funding Opportunity (NOFO) solicits cooperative agreement research applications to support a multidisciplinary program titled "Accelerating Product Excellence in Innovation and for Clinical Adoption" (APEx), that will facilitate advancement of promising strategies and products for tissue engineering and regenerative medicine (TE/RM). APEx will be composed of Resource Centers (RCs) and associated Interdisciplinary Translational Projects (ITPs) in the area of therapeutics (including adult stem cell-based treatments), sensors, and diagnostics. RCs will capitalize on their available clinical, scientific, industrial, regulatory and commercialization expertise, to deliver technical support, research capacity, administrative infrastructure and regulatory and commercialization support to the ITPs and guide them to complete pre-clinical studies toward initiation of clinical trials. During this funding cycle, APEx will complete validation, manufacturing, and preclinical testing of the most promising products, which may include, but are not limited to products for detecting or treating tissue damage caused by congenital defect, traumatic injury, or chronic disease. Products that support early detection of chronic pathologies, monitoring of validated biomarkers of health or disease, as well as approaches to reduce or prevent resulting damage, are especially encouraged. The outcome of APEx will be TE/RM products with their regulatory approvals in place for first-in-human studies, along with associated clinical study protocols, and synthesis and manufacturing protocols ready for initiation of clinical trials.

Who can apply

Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Public housing authorities/Indian housing authorities
Native American tribal governments (Federally recognized)
Public and State controlled institutions of higher education
For profit organizations other than small businesses
Private institutions of higher education
Small businesses
City or township governments
Independent school districts
Native American tribal organizations (other than Federally recognized tribal governments)
Special district governments
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
State governments
County governments

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

The official record

Grants.gov published the official terms and dates of this opportunity; this page keeps them as they were listed.

View on Grants.gov

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

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