Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional)
Federal funding opportunity PAR-25-444 from National Institutes of Health (Department of Health and Human Services).
Apply on Grants.gov →Application closes September 25, 2028
- Posted
- November 26, 2025
- Closes
- September 25, 2028
- Cost sharing
- No
- Instrument
- Grant
- Assistance listing
- 93.397
- Category
- Health
- Archives
- October 30, 2028
Program funding history
Awards made under Assistance Listing 93.397 across FY2024–FY2026, from public federal spending records.
- FY2024 obligated
- $589.4M
- FY2025 obligated
- $592.5M
- FY2026 (to date) obligated
- $195.2M
- Awards in window
- 345
Top recipients: Sloan-kettering Institute for Cancer Research, Dana-farber Cancer Institute, Inc., The Univeristy of Texas M.d. Anderson Cancer Center, The Johns Hopkins University, Fred Hutchinson Cancer Center
Source: USAspending.gov · refreshed July 2026
Synopsis
Who can apply
- For profit organizations other than small businesses
- Special district governments
- Independent school districts
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Native American tribal governments (Federally recognized)
- County governments
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Small businesses
- City or township governments
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- State governments
- Public and State controlled institutions of higher education
- Private institutions of higher education
Specific to this NOFO:For New (Type 1) applications, an applicant institution must have a funding base of $10,000,000 (Clinical Cancer Centers) or $6,000,000 (Basic Cancer Centers) in annual direct costs of NIH funding that is cancer-focused, as defined by the Research Condition and Disease Categorization (RCDC) system. Please contact the NCI Office of Cancer Centers (https://cancercenters.cancer.gov/) for assistance in determining the RCDC funding base.For Renewal (Type 2) applications, an applicant institution must have a funding base of at least $10,000,000 in annual direct costs of peer-reviewed, cancer-related funding. If the Cancer Center is an approved consortium of institutions, the funding base of the Center will be the sum of the funding bases of all participating institutions. However, funding (and other data) awarded to consortium partners may be included only if the partner has been previously evaluated in CCSG peer-review and approved by NCI.Example of NCI peer-reviewed mechanisms that may be included for determining eligibility to apply for a CCSG: DP1, DP2, R00, R01, R03, R15, R18, R21, R24, R25, R33, R35, R37, R41, R42, R50, R55, R56, P01, P20, P30s other than the CCSG, P50, SC1, SC2, U01, U10, U19, U24, U54, U56, UH2, UH3, UG3, T32, K and F series awards and N01s (excluding SEER and other N01s funding materials, services, or research resources). Cancer-relevant research funded by these mechanisms from other NIH Institutes may also be counted towards the minimum, as do cancer-relevant grants and contracts from the peer-reviewed funding sources listed in: https://cancercenters.cancer.gov/sites/default/files/PeerReviewFundingOrganizations.pdfNOTE: New (Type 1) applications cannot request evaluation for comprehensiveness status.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign…
How to apply
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