Open

Translational Neural Devices (R61/R33 - Clinical Trial Optional)

Federal funding opportunity PAR-25-053 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes January 28, 2027

Posted: October 29, 2024
Closes: January 28, 2027
Cost sharing: No
Instrument: Grant
Assistance listing: 93.853
Category: Health
Archives: March 5, 2027

Program funding history

Awards made under Assistance Listing 93.853 across FY2024–FY2026, from public federal spending records.

FY2024 obligated: $1.8B
FY2025 obligated: $1.8B
FY2026 (to date) obligated: $1.4B
Awards in window: 9,485

Top recipients: The General Hospital Corporation, Regents of the University of California, San Francisco, the, The Johns Hopkins University, Regents of the University of Michigan, The Trustees of Columbia University in the City of New York

Source: USAspending.gov · refreshed August 2026

Synopsis

The purpose of this Notice of Funding Opportunity (NOFO) is to encourage investigators to pursue translational activities and small clinical studies to advance the development of therapeutic, and diagnostic devices for disorders that affect the nervous or neuromuscular systems. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, obtaining an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, as well as a subsequent small clinical study. The clinical study is expected to provide information about the device function or final design that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. This NOFO is a milestone-driven cooperative agreement program and will involve participation of NIH program staff in negotiating the final project plan before award and monitoring of research progress.

Who can apply

Native American tribal governments (Federally recognized)
Others (see text field entitled "Additional Information on Eligibility" for clarification)
County governments
Independent school districts
Small businesses
Special district governments
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
Public and State controlled institutions of higher education
Public housing authorities/Indian housing authorities
City or township governments
For profit organizations other than small businesses
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
State governments

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.

View on Grants.gov Full announcement

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

New to federal funding? How to read an announcement · Who can apply · How grants work

Get grants like this every Tuesday — free

One email a week: the biggest new federal grants and what’s closing soon — the same list for everyone. Unsubscribe in one click.

The free edition carries one clearly labeled sponsor slot. No spam, ever. Privacy

Similar grants

Feasibility Clinical Trials of Mind and Body Interventions for NCCIH High Priority Research Topics (R34 Clinical Trial Required)
PAR-25-274 · National Institutes of Health · closes November 17, 2026
Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth (R01 Clinical Trial Required)
PAR-25-268 · National Institutes of Health · closes November 17, 2026
Limited Competition: Small Grant Program for the NCATS Clinical and Translational Science Award (CTSA) Program (R03 Clinical Trial Optional)
PAR-25-155 · National Institutes of Health · closes October 19, 2026
Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)
PAR-25-144 · National Institutes of Health · closes January 7, 2028
Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)
PAR-25-143 · National Institutes of Health · closes January 7, 2028
Dissemination and Implementation Research in Health (R03 Clinical Trial Not Allowed)
PAR-25-233 · National Institutes of Health · closes January 7, 2028

Same-day alerts, matched to you

The free digest is weekly — the same list for everyone. Members get an alert the day a matching federal grant posts: we read every new Grants.gov posting and score it, personalized to your organization. Free for 30 days, then $19/mo founding rate locked for life — the rate holds while your subscription stays active (Terms). Card required, cancel any time before day 31.

See pricing