In-Depth Phenotyping and Research Using IMPC-Generated Knockout Mouse Strains Exhibiting Embryonic or Perinatal Lethality or Subviability (R01 Clinical Trial Not Allowed)
- Posted
- January 12, 2023
- Closed
- November 5, 2024
- Award ceiling
- $499,999
- Cost sharing
- No
- Instrument
- Grant
- Assistance listing
- 93.313, 93.865, 93.121
- Archives
- December 5, 2024
Program funding history
Awards made under Assistance Listing 93.313 (one of 3 on this opportunity) across FY2025–FY2027, from public federal spending records.
- FY2025 obligated
- $0
- FY2026 obligated
- $0
- FY2027 (to date) obligated
- $0
- Awards in window
- 2
No net new obligations were recorded under this listing in the window shown: downward adjustments to earlier awards offset or exceeded new awards in every year. Awards in window counts awards with at least one recorded transaction in the window, adjustments included.
Source: USAspending.gov · refreshed October 2026
Synopsis
The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to phenotype and/or perform research on embryonic lethal knockout (KO) mouse strains being generated through the International Mouse Phenotyping Consortium (IMPC) of which the NIH Knockout Mouse Phenotyping Program (KOMP2) is a member. The mission of IMPC is to generate a comprehensive catalogue of mammalian gene function that will provide the foundation for functional analyses of human genetic variation. The current (July 19, 2022) IMPC data release includes phenotypic data for 8260 knockout genes. Overall, the IMPC hopes to generate a null mutant and undertake broad-based phenotyping for every gene in the mouse genome. About 30% of these strains are expected to be either embryonic or perinatal lethal, or subviable. However, a large portion of homozygous lethal mutations are expected to have viable heterozygous phenotypes. The scientific community has the unique opportunity to leverage these mouse strains while they are being created and bred as part of the IMPC adult mouse phenotyping effort to perform additional in-depth phenotyping and research.
Who can apply
- City or township governments
- Public and State controlled institutions of higher education
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Native American tribal governments (Federally recognized)
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Special district governments
- Private institutions of higher education
- County governments
- Native American tribal organizations (other than Federally recognized tribal governments)
- Small businesses
- Public housing authorities/Indian housing authorities
- For profit organizations other than small businesses
- State governments
- Independent school districts
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
The official record
Grants.gov published the official terms and dates of this opportunity; this page keeps them as they were listed.
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