Archived

Modulating Human Microbiome Function to Enhance Immune Responses Against Cancer (R21 Clinical Trial Not Allowed)

Federal funding opportunity PAR-22-062 from National Institutes of Health (Department of Health and Human Services).

Posted: November 3, 2021
Closed: January 7, 2025
Award ceiling: $275,000
Cost sharing: No
Instrument: Grant
Assistance listing: 93.396, 93.393
Category: Education, Health
Archives: February 12, 2025

Program funding history

Awards made under Assistance Listing 93.396 (one of 2 on this opportunity) across FY2025–FY2027, from public federal spending records.

FY2025 obligated: $914.3M
FY2026 obligated: $911.3M
FY2027 (to date) obligated: $0
Awards in window: 2,957

Top recipients: The Trustees of Columbia University in the City of New York, Sloan-kettering Institute for Cancer Research, The Univeristy of Texas M.d. Anderson Cancer Center, Icahn School of Medicine at Mount Sinai, Trustees of the University of Pennsylvania, the

Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →

This opportunity is archived. Applications are no longer accepted. Similar grants are listed below, and the free Tuesday digest carries the next ones like it.

Synopsis

The purpose of this Funding Opportunity Announcement (FOA) is to support exploratory/development basic research projects that elucidate mechanisms by which the human microbiome inhibit or enhance anti-tumor immune responses, and to identify potential novel molecular targets for cancer prevention strategies. Applications should be focused on delineating how host interactions with specific microbes (or consortia) or their metabolites targets immune responses that enhance or prevent inflammation-associated or sporadic tumor formation. Concentration, timing, and duration of administered beneficial microbes may alter its effectiveness and thus those parameters should be rigorously addressed in the application.

Who can apply

Public and State controlled institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal governments (Federally recognized)
Public housing authorities/Indian housing authorities
State governments
Native American tribal organizations (other than Federally recognized tribal governments)
County governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Independent school districts
Private institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Small businesses
Special district governments
For profit organizations other than small businesses
City or township governments

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

The official record

Grants.gov published the official terms and dates of this opportunity; this page keeps them as they were listed.

View on Grants.gov Full announcement

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

New to federal funding? How to read an announcement · Who can apply · How grants work

Tell me when this program posts again

This round has closed. One email the morning after this program is posted again under a new number (we watch for about two years), and one more about a week before that round closes (the next morning, if it is already closer than that). That is all this sends — it is not a newsletter signup.

Stored once per grant, used only for this watch’s emails; every one carries a one-click unsubscribe. Privacy

Get grants like this every Tuesday — free

One email a week: the biggest new federal grants and what’s closing soon — the same list for everyone. Unsubscribe any time.

No spam, ever. Privacy

Similar grants

Sustained Support for Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional)
RFA-CA-27-021 · National Institutes of Health · closes October 19, 2026
Advanced Development of Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional)
RFA-CA-27-020 · National Institutes of Health · closes October 19, 2026
Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed)
PAR-25-095 · National Institutes of Health · closes November 6, 2026
Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R21 Clinical Trials Not Allowed)
PAR-25-096 · National Institutes of Health · closes November 17, 2026
Population Approaches to Reducing Alcohol-related Cancer Risk (R01 Clinical Trial Optional)
PAR-25-221 · National Institutes of Health · closes January 7, 2027
Cancer Prevention and Control Clinical Trials Grant Program (R01 Clinical Trial Required)
PAR-25-167 · National Institutes of Health · closes January 7, 2027

Same-day alerts, matched to you

The free digest is weekly — the same list for everyone. Members get every open federal grant scored to their organization — and an alert the day a real match posts: we read every new posting the day it opens. Free for 30 days, then $29/mo. Card required, cancel any time before day 31.

Not ready for a subscription? A one-time Fit Report — $29 — scores every open federal grant to your organization once, by email within one business day.

See pricing