DOD Amyotrophic Lateral Sclerosis, Pilot Clinical Trial Award
- Posted
- April 18, 2025
- Closed
- August 27, 2025
- Program funding
- $5,600,000
- Expected awards
- 2
- Cost sharing
- No
- Instrument
- Grant
- Assistance listing
- 12.420
- Archives
- September 26, 2025
Program funding history
Awards made under Assistance Listing 12.420 across FY2025–FY2027, from public federal spending records.
- FY2025 obligated
- $1.3B
- FY2026 obligated
- $598.5M
- FY2027 (to date) obligated
- $0
- Awards in window
- 4,414
Top recipients: The Univeristy of Texas M.d. Anderson Cancer Center, Regents of the University of California, San Francisco, the, University of California, Los Angeles, Icahn School of Medicine at Mount Sinai, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →
Synopsis
Summary: The fiscal year 2025 (FY25) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Pilot Clinical Trial Award supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of Amyotrophic Lateral Sclerosis (ALS). Projects may range from phase 1 to small-scale phase 2 trials.
Applications must address one of the following focus areas:
Biomarker-Driven Interventions: Disease-modifying interventions, with mechanism-specific biomarkers to predict which clinical trial participants are likely to respond, demonstrate target engagement, and effects on the intended biological pathway.
Clinical Care: Improving aspects of clinical care and symptom management for ALS.
Distinctive Features: Funding from this award mechanism must support a clinical trial.
Projects proposing a therapeutic intervention (drug, biologic, and/or device) must incorporate biomarkers specific to the intervention into the trial design.
All applications are required to incorporate a Community Collaboration Plan, as described in Attachment 8 to optimize research impact.
The clinical trial should begin no later than 12 months after the award date or 18 months for FDA-regulated studies.
Who can apply
- Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"
The official record
Grants.gov published the official terms and dates of this opportunity; this page keeps them as they were listed.
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